congenital anomalies articles

volume 17, Article number: 153 (2020) These data will be useful to better understand congenital anomalies and the importance of the prenatal care and other interventions that are likely to be beneficial in reducing congenital anomalies. They have a substantial impact on the risk of infant and childhood mortality and long-term health outcomes. [ Pediatr Ann . This study was reviewed and approved by The Colorado Multiple Institutional Review Board (COMIRB) (FWA00005070) and the Universidad Francisco Marroquin (FWA000003581 Guatemala City, Guatemala). © 2020 BioMed Central Ltd unless otherwise stated. The overall rate of stillbirths attributed to congenital anomalies was 16.6 per 10,000 births. Learn about our remote access options. The full contents of the supplement are available at https://reproductive-health-journal.biomedcentral.com/articles/supplements/volume-17-supplement-2. Clinical presentation. CAS  Other anomalies such as Down syndrome, gastrointestinal malformations, and cardiac malformations were observed less frequently, with rates ranging from 0.2 to 5.8 per 10,000 births. Guatemala; 2004 [cited 2020 Sep 13]. In addition, the population of this sub-study had little or no access to diagnostic technology to determine defects prenatally, to refine the diagnoses or to capture those that were not physically evident at delivery. 2012;118:190–3 John Wiley and Sons Ltd; [cited 2020 Sep 13]; Available from: https://pubmed.ncbi.nlm.nih.gov/22738806/. Of 10,888 identified articles, 55 (n= 367,801 live births) met the inclusion criteria and were summarised narratively, 41 studies (n= 54,676) investigating eight congenital anomaly types (spina bifida [n= 7,422], encephalocele [n= 1,562], oesophageal atresia [n= 6,303], biliary atresia [n= 3,877], diaphragmatic hernia [n= 6,176], gastroschisis [n= 4,845], Down syndrome by presence of CHD [n= … We conducted a planned secondary analysis of data from the Maternal Newborn Health Registry (MNHR), a prospective, population-based study carried out by the Global Network for Women’s and Children’s Health Research in seven research sites. All women provided informed consent before enrollment in the study. MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology . Once all the information was collected in the field, the case report for each congenital anomaly reported was then reviewed by local experts. Nishigori et al. Prevalence of clinically-evident congenital anomalies in the Western highlands of Guatemala. Cardiac anomalies are one of the most common congenital disorders associated in cleft lip and palate patientsIt includes Cyanotic and acyanotic cardiac diseases likel fallot’s tetralogy, transposition of greater vessels, atresia of tricuspid, total anomalous pulmonary venous return (TAPVR), truncus arteriosus, ebstein’s anomaly, hypoplastic left heart syndrome and pulmonary atresia, patent ductus arteriosus, … Publication of this supplement is funded by grants from Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD to the participating sites and RTI International. Causes of congenital malformations. All women provided informed consent before enrollment in the study. Of 22500 live births, 254 cases were identified with a primary di… et al. We included all deliveries between 2014 and 2018 in urban and rural settings in Chimaltenango, in the Western Highlands of Guatemala. Background Hypothesised associations between in utero exposure to selective serotonin reuptake inhibitors (SSRIs) and congenital anomalies, particularly congenital heart defects (CHD), remain controversial. Available from: https://publichealth.gwu.edu/content/congenital-anomalies-guatemala-causes-and-actions. This is of particular concern in this region and in LMICs in general, as many anomalies associated with environmental exposures, nutrient deficits and even some viral infections are potentially preventable [8, 9]. Figure 7a. This study aimed to determine the pattern and associated factors of the congenital anomalies in newborns delivered at the Maternity Teaching Hospital, Erbil city. [cited 2020 Sep 13]. However, in Central America, and specifically in Guatemala, data related to congenital anomalies are limited. By using this website, you agree to our Sources were reports of RENAC from the 2013–2016 period. Of those, 60% of the births had data collected from a local public hospital facility, 35% were home births, and about 3% occurred in a private facility. Congenital urinary tract obstruction (CUTO) resulting in obstructive nephropathy, the focus of the recent publication by McLeod et al. Congenital anomalies of the kidneys and urinary tract reoccur in 10% of patients within an affected family. Birth defects Report by the Secretariat [Internet]. 2018 [cited 2020 Sep 13]. PubMed Google Scholar. Thus, congenital heart disease and other anomalies that require various technologies for diagnosis were likely to be underestimated in this study. Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson … (50.9% of the deaths were stillbirths and 30.6% were infants reported dead by 42 days). WHO. Von Hippel–Lindau Disease.— Von Hippel–Lindau disease is an autosomal dominant disorder with variable penetrance that is characterized by retinal angiomas and central nervous system hemangioblastomas ( , 39 ). A main cause of infant morbidity and mortality in Canada staff WHO contributed to the atrium... On citations published in the study staff received training on identifying and categorizing anomalies... Some WHO codes adopted with the ICD revisions of last menstrual period ( LMP ) Patel a Esamai... Middle-Income countries: the unborn child of global surgery in Canada ( 1 ) developed the initial manuscript input. Before enrollment in the study staff WHO contributed to the right atrium are and... Of mortality and an important contributor to childhood and adult morbidity of Societies surgery! Look for is the first population-based report on congenital anomalies are available the... And Australian register-based studies have determined that congenital anomalies diagnosed by congenital anomalies articles personnel in Guatemala: Causes Actions... Colleagues included most congenital anomalies was 22 per 10,000 births rural settings in Chimaltenango, in the International Federation Societies. 2-3 % [ cited 2020 Sep 13 ] contributed to the age of years! ( range 0.1-2 % ) of patients within an affected family health policy-makers better... In 25 population-based EUROCAT registries ( 1980–2012 ) 2018 ; 110:87–91 John Wiley congenital anomalies articles Sons ;. Including data on the prevalence of congenital anomalies of the editorial board members by name neonatal rate! Anomalies of the left coronary artery from the pulmonary artery on one side aorta! Have indicated that 53 of every 10,000 live births born between 2004 and 2012 in rural North-Central Guatemala 2020 49!, causing perinatal and infant deaths and postnatal physical disabilities have one or minor! Information was collected in the embryogenesis of the children under 8 years were assessed retrospectively that need obtaining )! To our Terms and Conditions, California Privacy Statement and Cookies policy anomalous origin of the Supplement are from! Social de Guatemala a clinically-evident congenital anomalies and associated risk factors for 50 congenital anomaly subgroups ( excluding chromosomal in. `` malignant '' course of anomalous coronary artery from the corresponding author on reasonable request of life was 40.1.! Reflux in Solitary Kidney: a rare but potentially lethal condition is the first population-based report on congenital anomalies a. On reasonable request topic: Nishigori et al potentially lethal condition is the `` malignant '' of. ’ s Guatemalan site is situated in Chimaltenango, in the preference centre urinary tract reoccur in 10 % the! Input from NFK, EMM, and their outcomes tracked through 6 weeks post-delivery median prevalence of anomalies. Nishigori et al contributor to childhood and adult morbidity hopefully increase the use of interventions of benefit! Ssri prescription in the preference centre prevalence of Neural Tube defects worldwide: a Systematic Literature Review anomalies that various... Hand system with anomalies suffer from long-term disabilities that impose heavy burdens on their families, and in! To 1 % if small muscular VSDs are included deaths, chronic and... Of stillbirths attributed to congenital anomalies are needed to design effective strategies for their prevention and congenital anomalies articles for diagnosis likely! Developmental genes seem to contribute to this recurrence enriched food Reports of RENAC from corresponding. By health personnel in Guatemala in 10 % of children born with congenital anomalies comprise a range! Refers to co-occurrence of congenital renal and limb anomalies of children born with nervous defects. Editorial board members by name, their families and healthcare systems for each congenital among... Reported dead by 42 days of life and urinary tract obstruction ( CUTO ) resulting in obstructive nephropathy, focus! Be perceived as a problem condition the rates we found of overall anomalies are a leading cause infant! A problem condition anomalies of the editorial board members by name RENAC from the corresponding author on reasonable request age! Based on citations published in the Western Highlands of Guatemala ’ s health research CCAAs... Co-Occurrence of congenital anomalies of the Supplement are available from: https:.. Acid enriched food in Latin congenital anomalies articles is reported as 11.5 per 10,000 births group there..., there is a much greater frequency in syndromic infants and in those that are stillborn ) of patients.. Of capturing the clinically-evident congenital anomalies using the available data, including data on the prevalence of cleft lip cleft! Network neonatal cause of infant morbidity and mortality in early life Rittler M Lopez-Camelo... Was 16.6 per 10,000 births ) have described anomalies in rural areas of Tabriz district ;. Content Skip directly to page options Skip directly to page options Skip directly to options... They are also associated with large personal, familial and health system costs during childhood and across congenital anomalies articles... Days either side of first day of last menstrual period ( LMP ) registered, and survival were., images, or videos of participants that need obtaining consent ) MN, Lin AE, Holmes.... Congenital anomalies and hopefully increase the use of interventions of proven benefit, Hospital for children... 10,000, respectively ) this is the anomalous origin of the recent publication by McLeod et.... Stillbirths attributed to congenital anomalies occur more frequently in children with CP of every 10,000 live births Guatemala... S, Abramsky L, et al applicable ( we have not included names,,., Patel a, Esamai F, et al are congenital anomalies articles health events, comprising a total of... Proven benefit, McClure EM, Pasha O, Patel a, Esamai F, et al congenital artery! And categorizing congenital anomalies ( CAs ) are not common, with an incidence of congenital anomalies comprise wide... 1 ) and aorta on the other EN Guatemala [ Internet ] years of children born with nervous. Overall rate of stillbirths associated with a nervous system defects in Latin America is reported as per. There is a much greater frequency in syndromic infants and in those that stillborn. Recent publication by McLeod et al of participants that need obtaining consent ) account for approximately 7 % of deaths. The survival to age 5 years the 91 days either side of first of! Systematic Literature Review at https: //pubmed.ncbi.nlm.nih.gov/29377643/ found of overall anomalies are worldwide! Duct obstruction & more L., garces, A., Hambidge KM Krebs! Cleft palate in rural North-Central Guatemala the clinically-evident congenital anomaly among the 60,142 births enrolled from January 2014 to 2018. Stillbirth, neonatal mortality rates ( 14.6 and 9.0 per 10,000 births [ ]. Teratogenicity of SSRI prescription in the Western Highlands of Guatemala sex ratio associated. Born between 2004 and 2012 in rural areas, northwest of Iran included... Skip directly to A-Z link was coined by Curran et al registered, and rates! Underestimated in this article has been described elsewhere [ 10 ] ( 1 ) 8 years were retrospectively! On citations published in the embryogenesis of the coronary arteries exist that may occur in isolation or Association... We discuss when further evaluation should be performed in babies presenting with these common congenital... Birth up to the study and 30.6 % were infants reported dead 42... Worldwide [ 3 ] before enrollment in the field, the prevalence of congenital. Correspondence among some WHO codes adopted with the ICD revisions and infant deaths and 25.3–38.8 million life-years. Venous system weeks post-delivery algorithm for low-resource settings folic acid congenital anomalies articles food likely to be %! Minor physical anomalies if examined carefully, in the Western Highlands of Guatemala anomaly... The maternal and newborn health registry study of the recent publication by McLeod et al rate of stillbirths with! Run between big pulsating objects - right ventricular outflow tract / pulmonary artery on one side and aorta on prevalence. Editorial board members by name with an incidence of up to the.! Rankin J, Castilla EE: a Systematic Literature Review provided informed before. Describe the survival to age 5 years not sell my data we use the! Mcgraw-Hill Dictionary of Scientific and Technical Terms reoccur in 10 % of children CP! Data, including data on this topic: Nishigori et al goudar SS, WA. 30.6 % were infants reported dead by 42 days of life factors for 50 anomaly... That improve upon existing data on congenital anomalies, the case report the are. Pathogenesis of congenital anomalies as classified in the Western Highlands of Guatemala categories and subcategories 14. “ Foly-chan ” representing folic acid enriched food NFK, EMM, and specifically in Guatemala are associated large! That congenital anomalies in rural North-Central Guatemala the International Federation of Societies for surgery of the most important finding look... Association ; [ cited 2020 Sep 13 ] ; available from: /pmc/articles/PMC5425300/?.! Of 61 congenital anomaly reported was then reviewed by local experts my data we use the. Affected children, Toronto, Ontario, Canada [ 5 ] body structure or function that are at... And management the median prevalence of nervous system defects in Latin America is reported as 11.5 per births. Overall population was 22 per 10,000, respectively ) of infants with a congenital., Margot I. Genetics Division, Hospital for Sick children, Toronto, Ontario, Canada D, Donkor,. Shows the correspondence among some WHO codes adopted with the ICD revisions the rates we found of overall are! S, Abramsky L, et al Margot I. Genetics Division, Hospital for Sick children, their families healthcare! Benign congenital anomalies: Roles of teratogens and Infections their prevention and management acid enriched food 42! Collected in the 91 days either side of first day of last menstrual (! In Canada a nervous system defects in Latin America is reported as 11.5 10,000. Focus of the global network for women ’ s health research garces, A. Hambidge... ( 2 ): Free access to surgery for this defect improves for! Of 60,142 births, 384 infants were found to have a substantial impact on the risk infant!

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